Phenotypic features of immunocompetent cells in I-II pregnancy trimesters in women with anamnese infertility

It is impossible to solve the socio-economic problem of increasing birth rate in Ukraine without determining mechanisms pregnancy disorders, among which immune ones occupy an important place, and developing individualized scientifically based therapy schemes. Purpose - determine characteristics levels immunocompetent blood cells on CD phenotype women with a history infertility at different stages pregnancy. Materials methods. With FACSCan cell cytofloorimeter (Becton Dickinson, USA) test Becton Dickinson systems (USA) determined using monoclonal antibodies (MCAs) differentiated lymphocyte antigens, activation markers (HLA-DR, CD25, CD69) or having inhibitory properties (CD158a) relative 436 non-pregnant (reference group n) 514 pregnant dates I II trimesters (groups a-e). Results. Against background reduced count increased granulocytes women, significantly high level T-L T-cytotoxic subpopulations were found their (CD3+CD8+HLA-DR+- CD3+CD8+Cd In this gestation period there also increase as number T-helpers (CD3+CD4+-L), expression membranes HLA-DR- CD25-molecules. first 10 weeks pregnancy, decrease molecules CD158a (KIR2DL1) NK T CD3+CD4+CD56+-cl B-lymphocytes (CD19+), well B-1a (CD19+CD5+) from 8 28 was noted. Conclusions. The peculiarities peripheral system according phenotypes make it possible observe dynamics most them (CD3+CD8+HLA-DR+-, CD3+CD8+CD56+-, CD. research carried out accordance principles Helsinki declaration. study protocol approved by Local ethics committee participating institution. informed consent patient obtained for conducting studies. No conflict interests declared authors. Key words: CD-phenotype, cells, infertility, flow cytometry.